Natural and ‘ In vitro ’ selected antigenic variants of influenza A virus (H2N2)
Identifieur interne : 001A96 ( Main/Exploration ); précédent : 001A95; suivant : 001A97Natural and ‘ In vitro ’ selected antigenic variants of influenza A virus (H2N2)
Auteurs : A. Natali [Italie] ; E. Pilotti [Italie] ; P. O. Valcavi [Italie] ; C. Chezzi [Italie] ; J. S. Oxford [Royaume-Uni]Source :
- Journal of Infection [ 0163-4453 ] ; 1998.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Anticorps antiviraux (sang), Anticorps monoclonaux, Antigènes viraux (immunologie), Femelle, Glycoprotéine hémagglutinine du virus influenza (immunologie), Grippe humaine (épidémiologie), Humains, Mâle, Répartition par âge, Sous-type H2N2 du virus de la grippe A, Sujet âgé, Sujet âgé de 80 ans ou plus, Tests d'inhibition de l'hémagglutination, Variation des antigènes, Virus de la grippe A (), Virus de la grippe A (immunologie), Études séroépidémiologiques.
- MESH :
- immunologie : Antigènes viraux, Glycoprotéine hémagglutinine du virus influenza, Virus de la grippe A.
- sang : Anticorps antiviraux.
- épidémiologie : Grippe humaine.
- Pascal (Inist)
- Adulte, Adulte d'âge moyen, Anticorps monoclonaux, Epidémiologie, Exploration microbiologique, Femelle, Grippe A, Humains, Influenzavirus A, Mâle, Prévalence, Répartition par âge, Sous-type H2N2 du virus de la grippe A, Soustype, Sujet âgé, Sujet âgé de 80 ans ou plus, Tests d'inhibition de l'hémagglutination, Typage, Variation antigénique, Variation des antigènes, Virus de la grippe A, Études séroépidémiologiques.
English descriptors
- KwdEn :
- Adult, Age Distribution, Aged, Aged, 80 and over, Antibodies, Monoclonal, Antibodies, Viral (blood), Antigenic Variation, Antigenic variation, Antigens, Viral (immunology), Epidemiology, Female, Hemagglutination Inhibition Tests, Hemagglutinin Glycoproteins, Influenza Virus (immunology), Humans, Influenza A, Influenza A Virus, H2N2 Subtype, Influenza A virus (classification), Influenza A virus (immunology), Influenza, Human (epidemiology), Influenzavirus A, Male, Microbiological investigation, Middle Aged, Prevalence, Seroepidemiologic Studies, Subtype, Typing.
- MESH :
- chemical , blood : Antibodies, Viral.
- chemical , immunology : Antigens, Viral, Hemagglutinin Glycoproteins, Influenza Virus.
- chemical : Antibodies, Monoclonal.
- classification : Influenza A virus.
- epidemiology : Influenza, Human.
- immunology : Influenza A virus.
- Adult, Age Distribution, Aged, Aged, 80 and over, Antigenic Variation, Female, Hemagglutination Inhibition Tests, Humans, Influenza A Virus, H2N2 Subtype, Male, Middle Aged, Seroepidemiologic Studies.
- Teeft :
- Antibody, Antigenic, Antigenic site, Antigenic sites, Antigenic variant, Antigenic variants, Antigenic variation, Epitope, Haemolysis, Haemolysis area, Influenza, Influenza infection, Influenza virus, Influenza virus hemagglutinin, Influenza viruses, Monoclonal, Monoclonal antibodies, Monoclonal antibody, Monoclonal antibody pressure, Natural variant, Natural variants, Original antigenic, Pandemic influenza, Parental, Parental virus, Positive sera, Previous studies, Serological, Serological analysis, Serological reactivity, Single epitope, Unilateral test, Variant, Virus, World health organization.
Abstract
We provide data on the prevalence of SRH antibody to influenza A/Singapore/1/57 (H2N2). Approximately 10.3% of sera had antibody to the influenza A (H2N2) subtype virus in comparison to the 36.90% of positive sera to a representative influenza A (H3N2) and 31.5% to influenza A (H2N1) viruses. The percentage of subjects with antibody constantly decreased from the older to the younger age groups. Persons born after 1968 were essentially seronegative, whereas subjects born before 1900, and in the decade 1950–1959, showed the highest antibody levels to influenza A (H2N2) viruses. These age groups also appared to have ‘protective’ levels of anti-HA antibody to influenza A (H2N2) virus. An antigenic variant of A/Singapore/1/57 virus was selected in the laboratory using a monoclonal antibody to HA. Serological comparison of the new in vitro variant with the parental virus and two naturally occurring viruses, namely A/England/12/64 and Tokyo/3/67, showed that certain human sera were able to distinguish the variant, indicating a restricted antibody repertoire in these adult and children's sera, providing an explanation of how such variants could actually arise in nature.
Url:
DOI: 10.1016/S0163-4453(98)90260-2
Affiliations:
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type="abstract" xml:lang="en">We provide data on the prevalence of SRH antibody to influenza A/Singapore/1/57 (H2N2). Approximately 10.3% of sera had antibody to the influenza A (H2N2) subtype virus in comparison to the 36.90% of positive sera to a representative influenza A (H3N2) and 31.5% to influenza A (H2N1) viruses. The percentage of subjects with antibody constantly decreased from the older to the younger age groups. Persons born after 1968 were essentially seronegative, whereas subjects born before 1900, and in the decade 1950–1959, showed the highest antibody levels to influenza A (H2N2) viruses. These age groups also appared to have ‘protective’ levels of anti-HA antibody to influenza A (H2N2) virus. An antigenic variant of A/Singapore/1/57 virus was selected in the laboratory using a monoclonal antibody to HA. Serological comparison of the new in vitro variant with the parental virus and two naturally occurring viruses, namely A/England/12/64 and Tokyo/3/67, showed that certain human sera were able to distinguish the variant, indicating a restricted antibody repertoire in these adult and children's sera, providing an explanation of how such variants could actually arise in nature.</div></front></TEI><affiliations><list><country><li>Italie</li><li>Royaume-Uni</li></country></list><tree><country name="Italie"><noRegion><name sortKey="Natali, A" sort="Natali, A" uniqKey="Natali A" first="A." last="Natali">A. Natali</name></noRegion><name sortKey="Chezzi, C" sort="Chezzi, C" uniqKey="Chezzi C" first="C." last="Chezzi">C. Chezzi</name><name sortKey="Pilotti, E" sort="Pilotti, E" uniqKey="Pilotti E" first="E." last="Pilotti">E. Pilotti</name><name sortKey="Valcavi, P O" sort="Valcavi, P O" uniqKey="Valcavi P" first="P. O." last="Valcavi">P. O. Valcavi</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Oxford, J S" sort="Oxford, J S" uniqKey="Oxford J" first="J. S." last="Oxford">J. S. Oxford</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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